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The MERCI and Multi MERCI Trial

Smith WS, Sung G, Saver JL, Budzik RF, Duckwiler G, Liebeskind DS, Lutsep HL, Rymer MM, Higashida RT, Starkman S, Gobin YP, and Multi MERCI Investigators. Mechanical Thrombectory for Acute Ischemic Stroke. Final Results of the Multi MERCI Trial. Stroke (published online ahead of print February 28, 2008).

Smith WS. Safety of Mechanical Thrombectomy and Intravenous Tissue Plasminogen Activator in Acute Ischemic Stroke. Results of the Multi Mechanical Embolus Removal in Cerebral Ischemia (MERCI) Trial, Part I. AJNR Am J Neuroradiol. 2006 Jun-Jul;27(6):1177-82.

Flint AC, Duckwiler GR, Budzik RF, Liebeskind DS, Smith WS. Mechanical Thrombectomy of Intracranial Internal Carotid Occlusion Pooled Results of the MERCI and Multi MERCI Part I Trials. Stroke. 2007 Apr;38(4):1274-80.

Smith WS, Sung G, Starkman S, Saver JL, Kidwell CS, Gobin YP, Lutsep HL, Nesbit GM, Grobelny T, Rymer MM, Silverman IE, Higashida RT, Budzik RF, Marks MP. Safety and Efficacy of Mechanical Embolectomy in Acute Ischemic Stroke: Results of the MERCI Trial. Stroke. 2005 Jul;36(7):1432-1438.

Duckwiler G, For the MERCI Trial Investigators. The MERCI Trial: An overview of the device design and clinical results for the Merci stroke treatment system. Endovascular Today. 2004 May;3(5):69-71.

Gobin YP, Starkman S, Duckwiler GR, Grobelny T, Kidwell CS, Jahan R, Pile-Spellman J, Segal A, Vinuela F, Saver JL. MERCI 1: a phase 1 study of Mechanical Embolus Removal in Cerebral Ischemia. Stroke. 2004 Dec;35(12):2848-54.


Stroke Center Development

Rymer MM, Debbie Summers, and Pooja Khatri. The Stroke Center Handbook: Organizing Care for Better Outcomes: A Guide to Stroke Center Development and Operations. Informa UK, 2007..

Rymer MM, Thrutchley DE; For the Stroke Team at the Mid America Brain and Stroke Institute. Organizing regional networks to increase acute stroke intervention. Neurol Res. 2005;27 Suppl 1:S9-16.

Alberts MJ, Latchaw RE, Selman WR, Shephard T, Hadley MN, Brass LM, Koroshetz W, Marler JR, Booss J, Zorowitz RD, Croft JB, Magnis E, Mulligan D, Jagoda A, O'Connor R, Crawley CM, Connors JJ, Rose-DeRanzy JA, Emr M, Warren M, Walker MD; Brain Attack Coalition. Recommendations for comprehensive stroke centers: a consensus statement from the Brain Attack Coalition. Stroke 2005 Jul;36(7):1597-616.

Fischer U, Arnold M, Nedeltchev K, Brekenfeld C, Ballinari P, Remonda L, Schroth G, Mattle HP. NIHSS score and arteriographic findings in acute ischemic stroke. Stroke. 2005 Oct;36(10):2121-5..

Mukhi S, Khaja A, Albright K, Barreto A, Wagner-Bartak N, Martin-Schild S, Merrick M, Grotta J, Weir R. Angiography Resource Utilization for Acute Intra-Arterial Therapy for Acute Ischemic Stroke. ASITN 4th Annual Meeting, July 30-August 3, 2007 – Podium Presentation.

Qureshi AI, Kirmani JF, Sayed MA, Safdar A, Ahmed S, Ferguson R, Hershey LA, Qazi KJ; Buffalo Metropolitan Area and Erie County Stroke Study Group. Time to hospital arrival, use of thrombolytics, and in-hospital outcomes in ischemic stroke. Neurology. 2005 Jun 28;64(12):2115-20.

Kleindorfer DO, Broderick JP, Khoury J, Flaherty ML, Woo D, Alwell K, Moomaw CJ, Pancioli A, Jauch E, Miller R, Kissela BM. Emergency department arrival times after acute ischemic stroke during the 1990s. Neurocrit Care. 2007;7(1):31-5.

Rosamond W, Flegal K, Friday G, Furie K, Go A, Greenlund K, Haase N, Ho M, Howard V, Kissela B, Kittner S, Lloyd-Jones D, McDermott M, Meigs J, Moy C, Nichol G, O'Donnell CJ, Roger V, Rumsfeld J, Sorlie P, Steinberger J, Thom T, Wasserthiel-Smoller S, Hong Y; American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Heart disease and stroke statistics--2007 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation. 2007 Feb 6;115(5):e69-171.

Suzuki S, Saver JL, Scott P, Jahan R, Duckwiler G, Starkman S, Su Y, Kidwell CS. Access to intra-arterial therapies for acute ischemic stroke: an analysis of the US population. AJNR Am J Neuroradiol. 2004 Nov-Dec;25(10):1802-6.

Saver JL. Time is brain--quantified. Stroke. 2006 Jan;37(1):263-6.


Pre-Hospital Diagnosis

Singer OC, Dvorak F, du Mesnil de Rochemont R, Lanfermann H, Sitzer M, Neumann-Haefelin T. A simple 3-item stroke scale: comparison with the National Institutes of Health Stroke Scale and prediction of middle cerebral artery occlusion. Stroke. 2005 Apr;36(4):773-6.

Kidwell CS, Starkman S, Eckstein M, Weems K, Saver JL. Identifying stroke in the field. Prospective validation of the Los Angeles prehospital stroke screen (LAPSS). Stroke. 2000 Jan;31(1):71-6.

Kothari RU, Pancioli A, Liu T, Brott T, Broderick J. Cincinnati Prehospital Stroke Scale: reproducibility and validity. Ann Emerg Med. 1999 Apr;33(4):373-8.

Greenwald I, Hall JK. Time is Brain. Journal of the EMS. 2005; 30(11):20-33.

Correlation Between Recanalization and Outcome

Rha JH, Saver JL. The impact of recanalization on ischemic stroke outcome: a meta-analysis. Stroke. 2007 Mar;38(3):967-73.


Imaging

González RG. Imaging-guided acute ischemic stroke therapy: From "time is brain" to "physiology is brain". AJNR Am J Neuroradiol. 2006 Apr;27(4):728-35. Review.

Rai AT. The Imaging for Acute Stroke: Nine case studies detailing the impact of imaging on stroke therapy. Endovascular Today. 2007 May;6(5):75-80.

Smith WS, Roberts HC, Chuang NA, Ong KC, Lee TJ, Johnston SC, Dillon WP. Safety and feasibility of a CT protocol for acute stroke: combined CT, CT angiography, and CT perfusion imaging in 53 consecutive patients. AJNR Am J Neuroradiol. 2003 Apr;24(4):688-90.

Wintermark M, Reichhart M, Cuisenaire O, Maeder P, Thiran JP, Schnyder P, Bogousslavsky J, Meuli R. Comparison of admission perfusion computed tomography and qualitative diffusion- and perfusion-weighted magnetic resonance imaging in acute stroke patients. Stroke. 2002 Aug;33(8):2025-31.

Smith WS, Tsao JW, Billings ME, Johnston SC, Hemphill JC 3rd, Bonovich DC, Dillon WP. Prognostic significance of angiographically confirmed large vessel intracranial occlusion in patients presenting with acute brain ischemia. Neurocrit Care. 2006;4(1):14-7.

Todo K, Moriwaki H, Saito K, Tanaka M, Oe H, Naritomi H. Early CT findings in unknown-onset and wake-up strokes. Cerebrovasc Dis. 2006;21(5-6):367-71.

Buck BH, Saver JL. A case of acute ischemic stroke: optimizing management with penumbra and vessel imaging. Nat Clin Pract Neurol. 2007 Aug;3(8):465-9.


Failed IV t-PA or Ineligible for IV t-PA

Ribo M, Alvarez-Sabín J, Montaner J, Romero F, Delgado P, Rubiera M, Delgado-Mederos R, Molina CA. Temporal profile of recanalization after intravenous tissue plasminogen activator: selecting patients for rescue reperfusion techniques. Stroke. 2006 Apr;37(4):1000-4.

Saqqur M, Uchino K, Demchuk AM, Molina CA, Garami Z, Calleja S, Akhtar N, Orouk FO, Salam A, Shuaib A, Alexandrov AV; CLOTBUST Investigators. Site of arterial occlusion identified by transcranial Doppler predicts the response to intravenous thrombolysis for stroke. Stroke. 2007 Mar;38(3):948-54.

Kidwell CS, Latour L, Saver JL, Alger JR, Starkman S, Duckwiler G, Jahan R, Vinuela F, Kang DW, Warach S. Thrombolytic Toxicity: Blood Brain Barrier Disruption in Human Ischemic Stroke. Cerebrovasc Dis. 2008 Feb 27;25(4):338-343

Mullen MT, McGarvey ML, Kasner SE. Safety and efficacy of thrombolytic therapy in postoperative cerebral infarctions. Neurol Clin. 2006 Nov;24(4):783-93.


Vasospasm in Acute Ischemic Stroke

Shah QA, Georgiadis A, Suri MF, Rodriguez G, Qureshi AI. Preliminary experience with intra-arterial nicardipine in patients with acute ischemic stroke. Neurocrit Care. 2007;7(1):53-7.


Clot Pathology

Marder VJ, Chute DJ, Starkman S, Abolian AM, Kidwell C, Liebeskind D, Ovbiagele B, Vinuela F, Duckwiler G, Jahan R, Vespa PM, Selco S, Rajajee V, Kim D, Sanossian N, Saver JL. Analysis of Thrombi Retrieved From Cerebral Arteries of Patients With Acute Ischemic Stroke. Stroke. 2006 Aug;37(8):2086-93.


Single Center Experiences

Kim D, Jahan R, Starkman S, Abolian A, Kidwell CS, Vinuela F, Duckwiler GR, Ovbiagele B, Vespa PM, Selco S, Rajajee V, Saver JL. Endovascular Mechanical Clot Retrieval in a Broad Ischemic Stroke Cohort. AJNR Am J Neuroradiol. 2006 Nov;27(10):2048-2052.

Devlin TG, Baxter BW, Feintuch TA, Desbiens NA. The merci retrieval system for acute stroke: the southeast regional stroke center experience. Neurocrit Care. 2007;6(1):11-21.


Other Publications

Gary R. Duckwiler, M.D. for the MERCI and Multi MERCI Investigators. Outcomes in M1 Versus Isolated M2 Strokes in Multi MERCI. ASITN 4th Annual Meeting, July 30-August 3, 2007 – Poster.

Doojin Kim, Reza Jahan, Jeffrey L Saver, David S Liebeskind, Fernando Vinuela, Sidney Starkman, Gary Duckwiler, for the MERCI and Multi MERCI Investigators. Mechanical Thrombectomy with the Merci Retriever for Acute Stroke in Very Elderly Patients. ASITN 4th Annual Meeting, July 30-August 3, 2007 – Podium Presentation.

Doojin Kim, David Liebeskind, Bruce Ovbiagele, Fernando Vinuela, Gary Duckwiler, Reza Jahan, Sid Starkman, Marilyn Rymer, Jeffrey Saver . Early Dramatic Recovery in Patients Treated in MERCI and Multi MERCI (Part 1).  Stroke. 2007 Feb;38(2):506(P95).

Doojin Kim, David Liebeskind, Bruce Ovbiagele, Fernando Vinuela, Gary Duckwiler, Reza Jahan, Sid Starkman, Jeffrey Saver; Univ of California, Los Angeles, Los Angeles, CA. Time to Recanalization for Endovascular Mechanical Thrombectomy Based on Data from Multi MERCI (Part 1). Stroke. 2007 Feb;38(2):507(P98).

Lutsep HL. Mechanical endovascular recanalization therapies.  Curr Opin Neurol. 2008 Feb;21(1):70-5.

Smith WS. Technology Insight: recanalization with drugs and devices during acute ischemic stroke. Nat Clin Pract Neurol. 2007 Jan;3(1):45-53.

Johnston SC, Hauser SL. Neurology and medical devices. Ann Neurol. 2006 Oct;60(4):11A-2A.

Edgell R, Yavagal DR. Acute endovascular stroke therapy. Curr Neurol Neurosci Rep. 2006 Nov;6(6):531-8.

Katz JM, Gobin YP. Merci Retriever in acute stroke treatment.  Expert Rev Med Devices.  2006 May;3(3):273-280.

Smith WS. Mechanical Intervention for Ischemic Stroke. US Neurological Disease 2006. Touch Briefings.

Katz JM, Gobin YP, Segal AZ, Riina HA. Mechanical embolectomy. Neurosurg Clin N Am. 2005 Jul;16(3):463-74.

Versnick EJ, Do HM, Albers GW, Tong DC, Marks MP. Mechanical thrombectomy for acute stroke. AJNR. 2005 Apr;26(4):875-9.

Xavier AR, Farkas J. Catheter-based recanalization techniques for acute ischemic stroke. Neuroimaging Clin N Am. 2005 May;15(2):441-53, xii.

Lutsep HL. Thrombolytic and newer mechanical device treatment for acute ischemic stroke. Expert Rev Neurother. 2006 Jul;6(7):1099-105.

Higashida RT. Recent advances in the interventional treatment of acute ischemic stroke. Cerebrovasc Dis. 2005;20 Suppl 2:140-7.

Barker E. A New Weapon to Combat Stroke. RN. 2006 March; 69(3):26-29.

Layton KF, White JB, Cloft HJ, Kallmes DF. Use of the Perclose ProGlide device with the 9 French Merci retrieval system. Neuroradiology. 2006 May;48(5):324-6.

Lutsep HL.  Mechanical Thrombolysis in Acute Stroke.  eMedicine: http://www.emedicine.com/neuro/topic702.htm

Felten RP, Ogden NR, Pena C, Provost MC, Schlosser MJ, Witten CM. The Food and Drug Administration medical device review process: clearance of a clot retriever for use in ischemic stroke. Stroke. 2005 Feb;36(2):404-6.


Case Publications

Ionita CC, Yamamoto J, Tummala RP, Levy EI. MRI assessment followed by successful mechanical recanalization of a complete tandem (internal carotid/middle cerebral artery) occlusion and reversal of a 10-hour fixed deficit. J Neuroimaging. 2008 Jan;18(1):93-5.

Layton KF, White JB, Cloft HJ, Kallmes DF, Manno EM. Expanding the treatment window with mechanical thrombectomy in acute ischemic stroke. Neuroradiology. 2006 Jun;48(6):402-4.

Martinez H, Zoarski GH, Obuchowski AM, Stallmayer MJ, Papangelou A, Airan-Javia S. Mechanical thrombectomy of the internal carotid artery and middle cerebral arteries for acute stroke by using the retriever device. Am J Neuroradiol. 2004 Nov-Dec;25(10):1812-5.

Yu W, Binder D, Foster-Barber A, Malek R, Smith WS, Higashida RT. Endovascular embolectomy of acute basilar artery occlusion. Neurology. 2003 Nov 25;61(10):1421-3.

Vora N, Thomas A, Germanwala A, Jovin T, Horowitz M. Retrieval of a displaced detachable coil and intracranial stent with an L5 merci retriever during endovascular embolization of an intracranial aneurysm. J Neuroimaging. 2008 Jan;18(1):81-4.

Parkinson RJ, Bendok BR, Getch CC, Yashar P, Shaibani A, Ankenbrandt W, Awad IA, Batjer HH. Retrograde suction decompression of giant paraclinoid aneurysms using a No. 7 French balloon-containing guide catheter. Technical note.
J Neurosurg. 2006 Sep;105(3):479-81.


Other Relevant Stroke Studies

Tissue plasminogen activator for acute ischemic stroke. The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group. N Engl J Med. 1995 Dec 14;333(24):1581-7.

Furlan A, Higashida R, Wechsler L, Gent M, Rowley H, Kase C, Pessin M, Ahuja A, Callahan F, Clark WM, Silver F, Rivera F. Intra-arterial prourokinase for acute ischemic stroke. The PROACT II study: a randomized controlled trial. Prolyse in Acute Cerebral Thromboembolism. JAMA. 1999 Dec 1;282(21):2003-11.

IMS II Trial Investigators. The Interventional Management of Stroke (IMS) II Study. Stroke. 2007 Jul;38(7):2127-35.

APM0208_B_3183 2008-03



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