Concentric Medical

We are a medical device company that designs, develops and markets products for restoring blood flow in patients who have suffered ischemic strokes, which result from blood clots in the vessels of the brain. Our Merci Retrieval System™ is designed to restore blood flow in the neurovasculature of ischemic stroke patients by removing blood clots. In 2004, we received clearance from the U.S. Food and Drug Administration, or FDA, for this indication, and our system is the only such FDA cleared device. We have also received FDA clearance to market our device for use in the retrieval of foreign bodies misplaced during the interventional radiological procedures in the neuro, peripheral and coronary vasculature. We believe that our Merci Retrieval System™ offers an option for ischemic stroke patients, who historically have had few other treatment options available. The Merci retrieval procedure is performed primarily by interventional neuroradiologists, and we estimate that over 6,000 patients have been treated to date with our system.

Stroke Market

According to the American Heart Association (AHA), stroke is the third leading cause of death and a leading cause of disability in the United States. The estimated direct and indirect costs of stroke in the United States in 2007 are estimated to exceed $62 billion. Stroke becomes more common with age, and approximately 75% of strokes occur in people over the age of 65. In addition to increasing age, risk factors for stroke include diabetes, cardiovascular disease, and obesity.

Over 700,000 strokes occur annually in the United States. Of all strokes in the United States, approximately 87% are ischemic, the result of a clot blocking blood flow in the vessels of the brain. Our Merci Retrieval System™ is designed to restore blood flow in large vessel ischemic strokes, which is where the blockage occurs in the vertebral, basilar, internal carotid, middle cerebral, anterior cerebral, and/or posterior cerebral arteries. We believe, based upon our review of published literature and our discussions with treating physicians, that 30% to 50% of all ischemic strokes in the U.S. are large vessel strokes.

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The Concentric Solution—The Merci Retrieval System™

The Merci Retrieval System™ is a minimally invasive, catheter based system comprised of three products: the Merci Retriever®, the Merci® Balloon Guide and the Merci® Microcatheter. The Merci retrieval procedure operates through a widely accepted mode of delivery, where the arterial system is accessed through the femoral artery in the groin. Our device is then navigated through the body to the brain using standard endovascular techniques.

APM0195_C_3091 2008-01